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pentobarbital will minimize the level or influence of loratadine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.pentobarbital decreases amounts of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers raise fee of toremifene metabolism, lowering the steady-p